New High Throughput NMR Spectroscopy Platform For INRS
Implementation of a new nuclear magnetic resonance (NMR) spectroscopy platform will provide professors Nicolas Doucet and Steven LaPlante of Centre INRS–Institut Armand-Frappier with a powerful new tool for conducting an ambitious research program aimed at identifying new therapeutic molecules. This new platform, funded in part by the Canadian Foundation for Innovation’s John R. Evans Leaders Fund and the Government of Quebec, will enable the two researchers to explore the role of atomic-scale molecular motions in protein and enzyme families involved in amyotrophic lateral sclerosis (ALS), diabetes, asthma, HIV, auto-immune disease, and cancer.
Pooling their parallel expertise in protein NMR and drug discovery, professors Doucet and LaPlante will have access to a 600 megahertz NMR spectrometer with high throughput screening capabilities to characterize biomolecular interactions between proteins and their ligands. The knowledge gained will be crucial to fragment-based drug discovery (FBDD), a new pharmaceutical approach aimed at developing targeted and more effective drugs that cause fewer side effects.
This new research capability has the potential to revolutionize drug development practices and to provide new impetus to the pharmaceutical industry in Quebec and across Canada. It will also offer a unique training environment for highly skilled biotechnology personnel.
This article has been republished from materials provided by INRS. Note: material may have been edited for length and content. For further information, please contact the cited source.
Targeted Drug Could be Used to Treat Advanced Cancers Located Anywhere in the BodyNews
A new targeted drug could be used to treat a small number of advanced cancers no matter where they grow in the body.READ MORE
Human Malaria Parasites Grown for the First Time in Dormant FormNews
One of the biggest obstacles to eradicating malaria is a dormant form of the parasite which is resistant to most antimalarial drugs and can reawaken years later, causing disease relapse. Researchers have shown they can grow the dormant parasite in engineered human liver tissue for several weeks, allowing them to closely study how the parasite becomes dormant, what vulnerabilities it may have, and how it springs back to life.READ MORE
Comments | 1 ADD COMMENT
Ana Aitawa | Jan 01, 2018
The global fragment-based drug discovery market is estimated to reach US$ 720 Million by 2021, growing at a CAGR of 10.6% from 2017 to 2021. Market by service type or component [fragment screening (biophysical techniques – NMR spectroscopy, DSF assay, fluorescence polarization, isothermal titration calorimetry, X-ray crystallography, SPR, bilayer interferometry, mass spectrometry, capillary electrophoresis, biochemical assays; non-biophysical techniques; fragment optimization), and end users (academic and research institutes, biopharmaceutical companies, and CROs). Major players include Astex Pharmaceuticals, Alveus Pharmaceuticals, Beactica AB, Charles River Laboratories International, Inc., Crown Bioscience, Inc., Emerald BioStructures, Evotec A.G., Kinetic Discovery, Proteros Fragments, Structure Based Design, Sygnature Discovery, and Sprint Bioscience AB. https://www.ihealthcareanalyst.com/report/fragment-based-drug-discovery-market/