New Research Suggests Declining Rate of Treatment Discoveries
News Jun 10, 2013
According to a study published in the June issue of the journal Health Affairs, there has been a decline in the extent to which new medical treatments are shown to be significantly more effective than placebos. The findings, says study co-author Mark Olfson, MD, MPH, “suggest that medical breakthroughs that offer large benefits above placebo are becoming less common. As a result, now may be a good time to emphasize research that compares established treatments with one another.”
The study authors randomly selected and analyzed 315 placebo-controlled trials that were reported in four leading medical journals between 1966 and 2010. They found that the average effect size, as measured by the odds ratio (which compares the odds of an outcome resulting from the treatment with the odds of that outcome in absence of the treatment) decreased from a peak of 4.51 (1971–80) to 1.36 (2001–2010).
While placebo-controlled studies are considered to be the gold standard for establishing treatment efficacy, the dwindling effect size over the roughly 40-year period supports the view that renewed attention should be given to research that compares treatments already known to be effective, in terms of outcomes that matter most to patients.
In light of the current study, notes Dr. Olfson, professor of clinical psychiatry at Columbia Psychiatry and a research psychiatrist at the New York State Psychiatric Institute, comparative effectiveness research may be an important direction for future clinical research. “With apparently declining yield from placebo-controlled studies, it makes good sense to place greater emphasis on comparing two or more treatments that are known to be effective, to evaluate whether there are meaningful differences in their tolerability, safety, and costs.”
Compound as Effective as FDA-Approved Drugs Against Life-Threatening InfectionsNews
Purdue University researchers have identified a new compound that in preliminary testing has shown itself to be as effective as antibiotics approved by the Food and Drug Administration to treat life-threatening infections while also appearing to be less susceptible to bacterial resistance.READ MORE
Chemists Design 'Mini-ecosystems' to Test Drug FunctionNews
Scripps Research scientists have solved a major problem in chemistry and drug development by using droplet-sized 'miniecosystems' to quickly see if a molecule can function as a potential therapeutic.READ MORE
Targeting the Engine Room of the Cancer CellNews
Researchers at Columbia University Irving Medical Center (CUIMC) have developed a highly innovative computational framework that can support personalized cancer treatment by matching individual tumors with the drugs or drug combinations that are most likely to kill them.READ MORE
Comments | 0 ADD COMMENT
10th Annual Congress on Drug Formulation & Analytical Techniques
Sep 03 - Sep 04, 2018