N-Heterocyclic Carbene/Brønsted Acid Cooperative Catalysis as a Powerful Tool in Organic Synthesis
News Aug 25, 2012
The interplay between metals and N-heterocyclic carbenes (NHCs) has provided a window of opportunities for the development of novel catalytic strategies within the past few years. The recent successful combination of Brønsted acids with NHCs has added a new dimension to the field of cooperative catalysis, enabling the stereoselective synthesis of functionalized pyrrolidin-2-ones as valuable scaffolds in heterocyclic chemistry. This Commentary will briefly highlight the concept of N-heterocyclic carbene/Brønsted acid cooperative catalysis as a new and powerful methodology in organic chemistry.
The article is published online in Beilsten Journal of Organic Chemistry and is free to access.
Catalysis is common in many industries such as pharmaceutical, specialty chemicals, agriculture, polymer and over 90% of chemicals are made from catalytic processes. Researchers have reported an asymmetric reaction that uses a cationic (positively charged) catalyst to convert racemic (equal mixture of two enantiomers) substrates to asymmetric product via an intriguing reaction route,READ MORE
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