NCATS and InSphero Announce Collaboration
InSphero AG today announced a collaboration with the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health, to identify anti-cancer agents with cytotoxic activity in 3D tumor models. In this joint project, NCATS will use patient-derived xenograft (PDX) tumor microtissues, provided by InSphero in its 384-well microtissue platform, to screen a library of anti-cancer agents for anti-tumor efficacy using assays that measure cell proliferation, tissue integrity, and tissue size.
“For cancer drug discovery, it is of critical importance to have models that are physiologically relevant,” says InSphero Chief Technology Officer and Co-founder Jens M. Kelm, Ph.D. “3D microtissue models provide a more accurate reflection of the tumor and its extracellular environment.” The latest generation of PDX-derived 3D tumor microtissues from InSphero capture the heterogeneity of tumor cell populations, making them ideal for investigating special tumor cell sub-populations, including cancer stem cells (CSCs) or tumor-initiating cells. These cells have self-renewal potential and are thought to drive tumor formation and metastasis. CSCs appear to be resistant to current chemotherapy and radiation-therapy treatments leading to cancer recurrence, thus there is a heightened interest among oncologists to be able to screen therapeutic agents that target CSCs and other tumor cell sub-populations.
“To unlock the full potential of more relevant models to foster drug development we need to be able to integrate patient-derived 3D cancer models into the drug screening process as early as possible,” says Dr. Kelm. InSphero will work closely with researchers at NCATS to evaluate how PDX-derived tumor microtissues can be applied in primary and secondary screening campaigns using small to mid-size compound libraries.
Our project with InSphero is another example of how NCATS fosters collaborations to explore novel technologies that may accelerate discovery of molecular therapeutic agents across multiple disease areas,” says Anton Simeonov, Ph.D., scientific director of NCATS’ Division of Pre-Clinical Innovation.
This article has been republished from materials provided by InSphero. Note: material may have been edited for length and content. For further information, please contact the cited source.
Researchers Awarded $28M for Illuminating Druggable Genome NIH GrantsNews
Researchers receive grants as part of the NIH program focused on experimental and informatics approaches to characterize understudied proteins from three gene families: ion channels, G protein-coupled receptors (GPCRs), and protein kinases.READ MORE
PhoreMost Completes $15M (£11M) Series-A Round to Enter Drug DiscoveryNews
Investment to fund expansion of operations and progression of drug target pipeline.READ MORE
Targeting a Leaky Protein that Causes ParalysisNews
A rare genetic disorder in which people are overcome suddenly with profound muscle weakness is caused by a hole in a membrane protein that allows sodium ions to leak across cell membranes. Compounds containing a chemical group called guanidinium can block the pore created by the mutation and stop the sodium leak without altering the voltage sensor’s ability to function.READ MORE
Comments | 0 ADD COMMENT
9th International Conference on Mass Spectrometry and Chromatography
Sep 21 - Sep 22, 2018