Oncodesign Enters into a Research Collaboration and License Agreement with Sanofi
News Sep 15, 2012
Oncodesign has announced that the company has entered into a strategic research collaboration with Sanofi to apply exclusively Oncodesign’s Nanocyclix® technology to several Sanofi kinase target programs.
Nanocyclix® is a proprietary medicinal chemistry technology and research platform based on macrocyclisation chemical methodology and knowledge that gives access to potent and selective kinase inhibitors based on shape complementarity in the ATP binding site of kinases.
In this way, unprecedented selectivity is achieved even among kinases with high homology. In addition, the technology allows rapid improvement in the pharmacokinetic properties of the Nanocyclix® leads based on established knowledge.
Oncodesign is the leader in the field of macrocyclic kinase inhibitors and proposes both partnership opportunities in its internal programs as well as applying the technology to its partner’s lead kinase programs.
“We are very pleased that Sanofi, a world leader amongst pharmaceutical companies, has selected Oncodesign as a partner for advancing their internal kinase programs. This agreement further validates the development of our company into a platform company with innovative technologies in medicinal chemistry and advanced oncological pharmacology," said Philippe Genne, Ph.D., chief executive officer and Oncodesign founder.
The application of Nanocyclix® to Sanofi’s kinase lead programs aims to allow for a quicker selection of development candidates for multiple undisclosed kinase targets in kinase families that are notoriously difficult to address.
Under the terms of the agreement, Oncodesign will exclusively apply its Nanocyclix® technology platform in multiple undisclosed Sanofi kinase programs for a number of therapeutic applications over a period of four years.
Oncodesign is entitled to a technology access fee and discovery, development, regulatory and commercial milestone payments totaling up to EUR 130 million and low single digit royalties on net sales.
"This new Agreement illustrates the leading position of Oncodesign in the kinase inhibitor field. Our Nanocyclix® technology is now clearly established as a high value, differentiating approach that gives access to next generation kinase inhibitors in multiple therapeutic indications,” said Jan Hoflack, Ph.D., chief scientific officer of Oncodesign.
Cell Recycling System Offers Therapeutic Entry Point for Rare Disease TreatmentNews
Scientists have demonstrated how an investigational drug works against a rare, fatal genetic disease, Niemann-Pick type C1 (NPC1).READ MORE
Bone Cancer Drug Targets Tumors, Spares Other OrgansNews
A study led by The University of Texas MD Anderson Cancer Center found a drug known as bone metastasis-targeting peptidomimetic (BMTP-11) has potential as a new therapeutic strategy for this devastating illness.READ MORE
Cancer Cells Force Normal Cells to Act Like Viruses, Helping Tumors SpreadNews
Researchers reveal how cancer cells force normal cells to act like viruses – allowing tumors to grow, resist treatment, and spread.READ MORE
Comments | 0 ADD COMMENT
EMBL Conference: European Conference of Life Science Funders and Foundations
Apr 19 - Apr 20, 2018
EMBL Course: Target Engagement in Biology and Drug Discovery
Feb 19 - Feb 23, 2018