One Giant Leap for the Future of Safe Drug Delivery
News Jun 30, 2016
By using an innovative 3D inkjet printing method, researchers from Chemical and Biological Engineering at the University of Sheffield have taken the biggest step yet in producing microscopic silk swimming devices that are biodegradable and harmless to a biological system.
This means that these devices have the potential to be used in the human body in the future in applications such as drug delivery and locating cancer cells.
This new technique allows the researchers to use safer, non-toxic materials, meaning the micro-rockets will not cause harm or injure any living tissue or biological environment. This is a significant development as previous devices have been expensive to produce, complicated to manufacture and made from polystyrene beads, carbon nanotubes or metals which have to be covered in a catalyst layer (such as platinum) to be able to swim successfully, these devices are usually less friendly to the biological environment they are placed in.
The rockets are just 300 microns in length and 100 microns in diameter, the thickness of a single human hair, and create their own thrust, allowing them to ‘swim’ through any bio fluid containing the fuel.
This is the first time these micro-rockets have been produced using a new reactive inkjet printing method, using a solution of dissolved silk mixed with an enzyme. This solution is then placed into a 3D inkjet printer, which, similar to normal inkjet printing, builds up layers of ink to create a column of the rocket.
By printing methanol on top of the printed solution it triggers a reaction which forms rigid rocket shape which traps the enzyme within a silk lattice structure. This enzyme acts as a catalyst, reacting with fuel molecules to produce bubbles that propel the rocket forward.
Using an enzyme as a catalyst and silk to form the rocket, produces a much safer device that is biodegradable, cheaper and simpler to makeway, removing a major barrier to micro-rockets becoming a reality outside of the lab.
Dr Xiubo Zhao, from The Department of Chemical and Biological Engineering at Sheffield states: “By using a natural enzyme like catalase and silk which are fully biodegradable, our devices are far more biocompatible than earlier swimming devices.”
“The inkjet printing technique also allows us to digitally define the shape of a rocket before it’s produced. This makes it a lot easier to optimise the shape in order to control the way the device swims.”
The End of the Breathalyzer?News
Engineers have developed a miniature, ultra-low power injectable biosensor that could be used for continuous, long-term alcohol monitoring. The chip is small enough to be implanted in the body just beneath the surface of the skin and is powered wirelessly by a wearable device, such as a smartwatch or patch.READ MORE
Fermentation Byproduct Suppresses Seizures in Nerve Agent PoisoningNews
A compound found in trace amounts in alcoholic beverages is more effective at combating seizures in rats exposed to an organophosphate nerve agent than the current recommended treatment.READ MORE
Comments | 0 ADD COMMENT
2nd International Conference and Exhibition on Nanomedicine and Drug Delivery
May 21 - May 23, 2018