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Optimizing Interactions Between Active Substances and Target Proteins

News   Jan 29, 2021 | Original story from Goethe University Frankfurt

 
Optimizing Interactions Between Active Substances and Target Proteins

Upper part: Long residence time. An inhibitor (left: stick model) binds to the signal molecule FAK (right: part oft the FAK protein depicted as calotte model with spheres). The structural change of FAK causes hydrophobic contacts (yellow, so-called DFG motif) and a long-lasting engagement. Lower part: Short residence time. PYK2 signal protein does not change its structure upon inhibitor binding, thus resulting in a fast inhibitor dissociation. Credit: Knapp Laboratory, Goethe University Frankfurt

 
 
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