Paclitaxel Poliglumex/Capecitabine Regimen Well Tolerated and Active in Metastatic Breast Cancer
News Jun 03, 2008
At the 2008 Annual Meeting of the American Society of Clinical Oncology (ASCO), data were presented from a phase II investigator-sponsored trial paclitaxel poliglumex (OPAXIO™, CT-2103) in combination with capecitabine in first-line treatment of patients with metastatic breast cancer (MBC).
The goals of the study were to explore the tolerability and objective anti-tumor response rate as well as the disease-free progression and survival times of the regimen.
Although the study did not meet its pre-defined endpoint of 21 or more responses in the first 41 patients, 20 patients (42 percent) of the 48 evaluable patients demonstrated a confirmed tumor response, including two complete responses and 18 partial responses.
The authors concluded the combination of paclitaxel poliglumex and capecitabine was well tolerated and active in MBC. OPAXIO is being developed by Cell Therapeutics, Inc.
"Given the convenient dosing schedule, a 15 minute infusion every 3 weeks, as well as no requirement for premedications and minimal hair loss associated with OPAXIO compared to other taxanes, the goal of the study was to determine if OPAXIO combined with capecitabine, an oral chemotherapy agent, as first- line therapy in metastatic breast cancer would prove to be an active and relatively well tolerated regimen," said Jack W. Singer, M.D., Chief Medical Officer of CTI.
"The severe toxicities included neutropenia without neutropenic fever, neuropathy, and cutaneous toxicity that is most likely from capecitabine. We agree with the authors conclusions that the combination of OPAXIO and capecitabine had efficacy similar to other taxane/capecitabine combinations and was well tolerated and active in this patient population."
Exposure to Low Levels of BPA during Pregnancy Can Lead to Altered Brain DevelopmentNews
New research in mice provides an explanation for how exposure to the widely used chemical bisphenol A (BPA) during pregnancy, even at levels lower than the regulated “safe” human exposure level, can lead to altered brain development and behavior later in life.READ MORE
Moving Toward a Future Free of Drug-Induced Hearing LossNews
A new special publication orchestrated by five of the nation's leading hearing experts compiles the latest research into hearing loss caused by drugs and solvents - how it occurs, how to treat it, and how to prevent it.READ MORE
3-D Tissue Model of Developing Heart Could Aid Drug Safety Testing for Pregnant WomenNews
Parents and doctors often have to consider the mother's health as well as the potential risk regarding how medication could affect their baby. Researchers have developed a process to make a 3D tissue model that could mimic early stage human heart development, which could aid drug safety testing and help determine a drug's effects on fetal development.READ MORE
Comments | 0 ADD COMMENT
World Congress on Pathology and Laboratory Medicine
Sep 10 - Sep 11, 2018
10th International Conference on Mass Spectrometry and Chromatography
Oct 08 - Oct 09, 2018