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Parallel Screening of Catalytic Ligands

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Radleys have announced a new application report that describes how the Cooled Carousel 12 Reaction Station has enabled the Faculty of Natural Sciences, Comenius University (Bratislava, Slovakia) to improve the structure of chiral ligands used for Palladium catalysed allylic alkylation reactions.

Ferrocenophane ligands are known to be useful catalysts for Pd-catalysed allylic alkylation, giving allylation product in high yields and with enantioselectivity.

In order to improve the ligand structure and obtain higher enantioselectivities the Comenius research group used the Cooled Carousel Reaction Station to run a series of carefully controlled parallel test reactions. Running test reactions using different ligands and varying parameters in parallel the Comenius research group were able to accelerate the reaction optimisation process.

The Cooled Carousel Reaction Station can bring all the benefits of parallel synthesis to applications that require sub-ambient temperatures down to -70°C. Based on the patented Carousel design, the Cooled Carousel can fit onto a standard stirrer and can simultaneously perform a choice of six or twelve cooled and stirred parallel solution phase or solid supported reagent based syntheses.

A central gas inlet and radial gas distribution system, combined with gas-tight PTFE caps, can allow cooled reactions to be carried out under an inert atmosphere.