Patent for Nano-scale Detection of Ion Channel Function in Lipoparticles
News Feb 21, 2013
The U.S. patent covers the application of Integral Molecular’s Lipoparticle technology for deriving high concentrations of functional ion channels for drug screening, antibody development, and biomedical research. Ion channels are important therapeutic targets for a wide range of human diseases and comprise approximately 15% of existing drug targets. Lipoparticle technology stems from research conducted at the University of Pennsylvania and published in the journals Science, PNAS, and Journal of Virology. US Patent No. 8,377,691 was issued by the U.S. Patent and Trademark Office on February 19, 2013 to Integral Molecular.
“The Lipoparticle technology overcomes many of the challenges of conventional electrophysiological approaches for screening ion channel targets, which have largely been limited to studies with live cells or reconstituted lipid bilayers,” said Dr. Benjamin Doranz, Chief Scientific Officer at Integral Molecular and the inventor of the technology. “Development and validation of the Lipoparticle ion channel technology enabled Integral Molecular to successfully implement high-throughput screening (HTS) campaigns against ion channels, including the identification of novel anti-influenza lead compounds.”
Integral Molecular offers custom-produced Lipoparticles with user-specified membrane proteins, as well as ReadyReceptor® Lipoparticles that contain pre-validated high-concentration membrane protein targets such as GPCRs, transporters, and ion channels. Each lot of Lipoparticles is quality controlled and provided with technical protocols for relevant applications, including antibody screening, biosensor assays, ELISA binding assays, and functional assays. Lipoparticles can be biotinylated or fluorescently labeled to accommodate specialized applications.
Researchers Awarded $28M for Illuminating Druggable Genome NIH GrantsNews
Researchers receive grants as part of the NIH program focused on experimental and informatics approaches to characterize understudied proteins from three gene families: ion channels, G protein-coupled receptors (GPCRs), and protein kinases.READ MORE
PhoreMost Completes $15M (£11M) Series-A Round to Enter Drug DiscoveryNews
Investment to fund expansion of operations and progression of drug target pipeline.READ MORE
Targeting a Leaky Protein that Causes ParalysisNews
A rare genetic disorder in which people are overcome suddenly with profound muscle weakness is caused by a hole in a membrane protein that allows sodium ions to leak across cell membranes. Compounds containing a chemical group called guanidinium can block the pore created by the mutation and stop the sodium leak without altering the voltage sensor’s ability to function.READ MORE
Comments | 0 ADD COMMENT
9th International Conference on Mass Spectrometry and Chromatography
Sep 21 - Sep 22, 2018