We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Plant Compound Has Therapeutic Effect on Complications from Snakebites
News

Plant Compound Has Therapeutic Effect on Complications from Snakebites

Plant Compound Has Therapeutic Effect on Complications from Snakebites
News

Plant Compound Has Therapeutic Effect on Complications from Snakebites

Jararaca (Bothrops jararaca). This photo was taken circa 2002 in Itatiaia, Rio de Janeiro, Brazil. Credit: Felipesussekind, Flickr, 2002. Available at: https://www.flickr.com/photos/felipesussekind/5992689190/
Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Plant Compound Has Therapeutic Effect on Complications from Snakebites"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Rutin, a flavonoid, may complement antivenom as an effective co-treatment for envenoming from Bothrops jaraca.

Researchers have found that rutin, an inexpensive, plant-based compound may protect envenomed mice from bleeding and inflammation problems, according to a study published in PLOS Neglected Tropical Diseases by Ana Teresa Azevedo Sachetto of Institute Butantan, São Paulo, Brazil.

Anti-venom can effectively treat the major manifestations of snakebites, however, there are no known therapies effective for common secondary complications. Venom toxins from Bothrops jaraca (lance-headed vipers) may trigger bleeding, disrupt oxidation reduction in cells, and inhibit the body's ability to stop bleeding. Researchers injected both venom and rutin into a group of mice, then analyzed blood and tissue samples to understand what effect(s) if any, the rutin had on pathophysiological events triggered by Bothrops jararaca venom.

The mechanisms of clinical complications in patients bitten by B. jaraca snakes are not well understood and antivenom therapy is limited in its ability to treat the full array of complications that may occur following a snakebite. Future studies will be necessary to understand rutin activity once venom has initiated pathophysiological events, as well the therapeutic effects of rutin delivered with antivenom. According to the authors, the research "indicates that rutin has a great potential as an ancillary drug in concert with antivenom therapy to treat snakebites, particularly in countries where antivenom availability is scarce."

This article has been republished from materials provided by PLOS Neglected Tropical Diseases. Note: material may have been edited for length and content. For further information, please contact the cited source.

Reference

Sachetto ATA, Rosa JG, Santoro ML (2018) Rutin (quercetin-3-rutinoside) modulates the hemostatic disturbances and redox imbalance induced by Bothrops jararacasnake venom in mice. PLOS Neglected Tropical Diseases 12(10): e0006774. https://doi.org/10.1371/journal.pntd.0006774 

Advertisement