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Potential for Anti-Chagas Therapies Using Structure-based Drug Design

News   Sep 27, 2017 | Original story from Tokyo Institute of Technology

 
Potential for Anti-Chagas Therapies Using Structure-based Drug Design

Results of the TcSpdSyn-ligand docking analysis. Docking poses of the top five compounds (green: docking results, pink: dcSAM). This simulation was conducted with the TcSpdSyn X-ray structure (PDB ID code: 3BWC). The docking results show that all compounds bind to the putrescine-binding site and that dcSAM binding in its own site. Credit: Yoshino, R. et al. Sci Rep. (2017). doi:10.1038/s41598-017-06411-9

 
 
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