Probiotic Treatment Stops Superantigens That Cause Toxic Shock Syndrome
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Summary
The article highlights the potential of probiotics, including Lactobacillus strains, in preventing toxic shock syndrome (TSS) caused by pathogenic Staphylococcus aureus. Probiotics inhibit TSS-triggering superantigens and offer a promising solution to reduce TSS risk, especially in menstruating individuals and vulnerable populations.
Key takeaways
- Probiotics, such as Lactobacillus acidophilus and Lacticaseibacillus rhamnosus, can inhibit the production of superantigens causing toxic shock syndrome (TSS) from Staphylococcus aureus in lab experiments.
- The combination of L. acidophilus and L. rhamnosus can prevent S. aureus growth and inhibit the immune response, potentially reducing the risk of TSS in menstruating individuals.
- Probiotics, specifically L. crispatus, could offer effective action against pathogenic S. aureus, suggesting a promising way to reduce the risk of TSS and enterocolitis in vulnerable populations and prevent skin staph infections.
Inhibition of production of the superantigens that cause TSS
The widespread, pathogenic microbe Staphylococcus aureus can colonize the skin and mucous membranes throughout the body, particularly the vagina and gastrointestinal tract. A virulent strain of the bacterium produces proteins that trigger toxic shock syndrome (TSS), a disease characterized by the quick onset of fever, a telltale rash and, without treatment, multi-organ failure. In the vagina, TSS is associated with a life-threatening reaction from the immune system.
Probiotics may help prevent the disease before the cytokine cascade ever begins. A study published in the American Society for Microbiology’s journal Microbiology Spectrum reports that strains of 2 bacteria, Lactobacillus acidophilus and Lacticaseibacillus rhamnosus, successfully inhibited the production of the superantigens that cause TSS, in lab experiments. L. acidophilus, in addition, inhibited the growth of the S. aureus strains that produce the problematic proteins.
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He noted that adding these probiotics to tampons or other menstrual products could reduce the risk—and global incidence—of TSS associated with menstruation. Such a preventive measure has the potential to benefit millions of vulnerable people, according to Schlievert. “We know that 20% of people over age 12 cannot make antibodies and never will make antibodies against toxic shock syndrome,” he said.
Schlievert has been studying TSS and its prevention for decades. In the early 1980s, he was the first researcher to identify the toxin that triggers an overreaction of the immune system, and to show how high-absorbency tampons facilitated production of that toxin if S. aureus was present.
The new work, he said, was motivated by observations made during an earlier study. A few years ago, he and his colleagues recruited 205 women to test whether a novel molecular mixture, when added to tampons, would inhibit pathogenic bacteria. That molecule proved effective against E. coli and other pathogens, but the researchers noticed an unexpected consequence.
“Some of the women in the treatment group had this tremendous growth of Lactobacilli,” Schlievert said.
Further studies revealed that 9 of those women were colonized with only L. crispatus and no other bacteria. In microbiology research, Schlievert said, colonization by a single bacterium is often regarded as unhealthy. In this case, however, it offered an effective action against pathogenic S. aureus.
Lactobacillus bacteria have already been shown to be safe, Schlievert said, and the new work suggests that treatment with L. crispatus alone, or L. acidophilus and L. rhamnosus in combination, could dramatically reduce the risk of TSS in vulnerable populations. Strains of S. aureus can also cause enterocolitis, a life-threatening immune response in the gut. Probiotics may also help reduce the production of dangerous proteins for that disease, said Schlievert.
In ongoing and future work, Schlievert and his team are investigating how to use probiotics to prevent skin staph infections. The skin of people with atopic dermatitis, or with type 2 diabetes, is often colonized with the strains of S. aureus that produce superantigens, which are often resistant to treatment with standard antibiotics. In patients with type 2 diabetes, those superantigens could lead to foot ulcers that, if not treated successfully, could lead to amputation.
Schlievert sees probiotics as a promising way to prevent those complications. “If we can improve their lives by using this approach, that would be wonderful.”
Reference: Schlievert PM, Gaitán AV, Kilgore SH, et al. Inhibition of Toxic Shock Syndrome-Associated Staphylococcus aureus by Probiotic Lactobacilli. LaRock CN, ed. Microbiol Spectr. 2023:e01735-23. doi: 10.1128/spectrum.01735-23
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