Prokarium Acquires Key Oral Vaccine Technology from Emergent BioSolutions
News Jul 10, 2012
Prokarium Ltd has completed a key technology acquisition from Emergent BioSolutions Inc., a global biopharmaceutical company based in Maryland, USA.
The technology includes Emergent’s live Salmonella-based typhoid vaccine Typhella™ and its genetic technology spi-VEC™.
Prokarium will combine Typhella™ and spi-VEC™ with its proprietary genetic and formulation technologies to form Vaxonella™, a versatile oral vaccine delivery platform.
Emergent has successfully conducted several phase 1 and 2 clinical trials, which have shown Typhella™ to be safe and immunogenic as a typhoid vaccine.
The combination with Prokarium’s plasmid stabilization technology ORT-VAC™, will enable the delivery of recombinant protein vaccines without needles or adjuvants.
Prokarium plans to offer this Vaxonella™ platform to the biotech community on a licensing basis.
Prokarium will focus on the development of a dual oral vaccine against typhoid and ETEC (enterotoxigenic E. coli - a major cause of diarrhoea) for travellers and developing country markets.
There are 22 million cases of typhoid every year resulting in 200,000 deaths, so an effective oral vaccine could have a significant impact.
Currently there is no dedicated vaccine against ETEC, considered responsible for 300,000 - 500,000 deaths per year, mostly of young children.
Dr Rocky Cranenburgh, Prokarium’s Chief Scientific Officer, said “I am delighted with the acquisition of this technology from Emergent; the combination of their Salmonella vector with Prokarium’s technologies allows us to develop an advanced oral delivery platform which gives Prokarium the potential to revolutionize vaccinations”.
Researchers Discover Key Link Between Mitochondria and Cocaine AddictionNews
Researchers were able to block response in mitochondria to cocaine.
Insulin Goes Viral: Diabetes and Cancer-causing Mechanisms ExploredNews
Every cell in your body responds to the hormone insulin, and if that process starts to fail, you get diabetes. In an unexpected finding, scientists have identified four viruses that can produce insulin-like hormones that are active on human cells. The discovery brings new possibilities for revealing biological mechanisms that may cause diabetes or cancer.READ MORE
Tuberculosis Vaccine Trial Results Offer Potential for BCG RevaccinationNews
The study is the first 'prevention of infection' trial conducted for tuberculosis, the world's leading infectious disease killer.READ MORE