Prosonix Confirms the Potential of its Multi-component Particle™ Technology
News Sep 11, 2014
Prosonix has announced that it has confirmed the potential of its Multi-component Particle™ (MCP™) Technology for creating novel inhaled, dual and triple fixed dose combination (FDC) therapies for respiratory diseases. The Company will use the information generated to advance one or more candidates into formal development studies in the coming months.
Prosonix’ MCP™ Technology allows the combination of two or more active drug molecules in a pre-determined and constant ratio into a single drug-only particle, without the need for additional excipients.
The resultant formulations thereof could facilitate for the first time the therapeutic labelled dose to be delivered precisely to the site of action in the lung in a targeted fashion from a single pressurized metered dose inhaler (pMDI) or dry powder inhaler (DPI) device.
MCP™ based formulations created by Prosonix include optimally engineered dual and triple combinations of known drug products, including inhaled corticosteroids (ICS), long-acting beta-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs).
In addition, these uniquely engineered FDCs offer the potential for enhanced localized synergistic pharmacological effect, dose sparing and compliance, as well as administration via simple, cost-effective inhaler devices.
The announcement marks the successful conclusion of a comprehensive research programme led by Prosonix as part of a consortium including internationally recognized respiratory disease and drug inhalation experts: Professor Peter Barnes and Dr Omar Usmani at Imperial College London, Dr Ben Forbes at King’s College London and Professor Rob Price at the University of Bath.
The consortium was supported by a funding award from the Biomedical Catalyst, an integrated translational funding programme jointly operated by the UK Medical Research Council and the UK’s innovation agency, the Technology Strategy Board. The programme involved multiple aspects of manufacturability, in vitro and ex vivo testing, and the development of new biologically relevant models.
David Hipkiss, Prosonix’ CEO, said: “We are delighted that the outcome of the Biomedical Catalyst programme has confirmed the potential of our MCP™ Technology as a basis for the development of cost-effective fixed dose combination therapies for respiratory diseases. Such combinations, in particular triple FDCs, are expected to become the mainstay of therapy in a large proportion of COPD patients over the coming years as they are anticipated to have important clinical, patient and payer benefits, being more convenient and more cost-effective than the current standard of care, which involves taking multiple medications from separate, often diverse, devices. We thank our collaborators for their valuable contributions to this project and we look forward to selecting candidates for formal development studies over the coming months.”
PhoreMost and Plexxikon Collaborate to Identify Novel Drug TargetsNews
PhoreMost, the UK-based biopharmaceutical company dedicated to drugging ‘undruggable’ disease targets, today announced it has signed a collaborative agreement with Plexxikon Inc., the small molecule structure-guided R&D centre of Daiichi Sankyo.READ MORE
Anti-Malaria Drugs Delivered With CaffeineNews
Many drug delivery systems, such as capsules and tablets, can be difficult to swallow, especially for children. Making delivery systems out of polymer gels is an attractive option, but usually requires hazardous levels of heavy metals to be used. Now, scientists have found a way to build these gels from caffeine molecules.READ MORE
Lonza Opens World’s Largest Dedicated Cell-and-Gene-Therapy Manufacturing Facility in TexasNews
First-of-its-kind, state-of-the-art manufacturing facility with capacity to produce treatment for thousands of patients suffering from rare genetic disorders or life-threatening diseases.READ MORE