Prosonix Enters Collaboration with Imperial College London
News Jul 05, 2012
Prosonix has announced that it has signed a Collaborative Research Agreement with Imperial College London to accelerate the development of engineered Multi-component Particles (MCPs™) as respiratory medicines.
The collaboration will see Prosonix working closely with Dr Omar Usmani, an internationally recognized expert in respiratory diseases and inhaled drug delivery at the College’s National Heart and Lung Institute (NHLI).
Its aim is to develop a deeper understanding of how MCPs can be translated into new respiratory medicines with significant clinical benefits compared to existing combination formulations in chronic obstructive pulmonary disease (COPD) and asthma.
Results from the collaboration are intended to accelerate the development of Prosonix’ PSX2000 MCP Series of novel combination medicines, with the aim of advancing one or more MCP candidates into formal preclinical/proof of concept studies in 2013.
Prosonix’ drug particle engineering approach and expertise has enabled the development of MCPs that combine two active respiratory drug molecules consistently in a pre-determined ratio in each and every particle in the formulation, without the need for additional excipients.
The scope of the collaboration is to investigate MCPs in in vitro and in vivo models of the lung. It will also compare key performance criteria, including synergistic effects in reducing inflammation and improving bronchodilation resulting from co-localization of active drug components, with other combination formulations including marketed combination products.
Excipient-free, drug-only MCPs engineered by Prosonix that will be evaluated in the project include:
• Inhaled corticosteroids (ICS) with long-acting beta-agonist (LABA), and
• LABAs with long-acting muscarinic antagonists (LAMA)
David Hipkiss, Prosonix’ CEO, said: “Our strong links with the world’s leading academic research groups focused on respiratory medicine and inhaled drug delivery, such as Dr Omar Usmani’s group at Imperial College’s NHLI and Professor Rob Price’s team at the University of Bath, alongside our own development team, ensure that Prosonix retains a pre-eminent position in the field. We believe that our particle engineering technology is potentially transformational in enabling the development of novel inhaled combination therapies that deliver significant clinical benefits. Following the recent second close of our £17.1M financing, we believe we are very well placed now to drive the development of our unique MCPs into the clinic.”
Dr Omar Usmani said: “Co-localization of active components in respiratory drug combinations in the lung may offer the potential for an enhanced clinical effect and therapeutic efficacy that is currently not fully achieved with current combinations. With better treatment of respiratory diseases requiring improved combinations for these reasons, we are extremely interested in Prosonix’ particle engineering approach and multi-component particles to determine whether they can demonstrate clinical synergy and thus provide a novel and effective means of delivering respiratory combinations.”
Lonza Expands Encapsulation and HPAPI Capabilities in North AmericaNews
Expanding our capabilities into commercial-scale encapsulation responds to our customers' desire to maintain programs at the Tampa, FL (USA) site from clinical development to commercialization.READ MORE
Researchers Discover Key Link Between Mitochondria and Cocaine AddictionNews
Researchers were able to block response in mitochondria to cocaine.READ MORE
'Click Chemistry' Reactions Could Boost Cancer-Fighting Drug PotencyNews
Researchers at The Scripps Research Institute (TSRI) have developed a quick and easy way to simultaneously modify dozens of drugs or molecules to improve their disease-fighting properties.READ MORE
Comments | 0 ADD COMMENT
World Advanced Therapies & Regenerative Medicine Congress
May 16 - May 18, 2018