Search for Cancer Drug Candidates
News Apr 10, 2015
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded $1.2 million from the National Cancer Institute of the National Institutes of Health (NIH) to accelerate the development of drug candidates to curb one of the most important drivers of human cancer.
TSRI Associate Professors Joseph Kissil and Louis Scampavia will be co-principal investigators for the three-year grant, which will focus on the “Hippo-YAP signaling pathway.”
“This pathway, which was discovered less than a decade ago, appears to regulate processes that are closely linked to an increasing number of cancers,” Kissil said. “The more we study it, the more we see its involvement. This new grant will help expand our investigation.”
The Hippo-YAP signaling pathway has been found active in breast, colorectal and liver cancers, in hepatocellular and squamous cell carcinoma, and in melanoma of the eye. Cancers initiated through this pathway tend to thrive and proliferate, relatively immune to destruction from programmed cell death.
Kissil, Scampavia and their colleagues plan to use Scripps Florida’s ultra-high-throughput screening resources and the campus’s library of more than 600,000 compounds to develop a series of screens to identify and optimize compounds to target the pathway and combat cancer.
The number of the grant is 1R01CA184277.
Quotient Sciences Acquires Pharmaterials, a UK-based Contract Development and Manufacturing OrganizationNews
Quotient Sciences, the drug development services organization, announces it has acquired Pharmaterials, a contract development and manufacturing organization (CDMO) based in Reading, U.K..READ MORE
BOC Sciences Continues to Enlarge Its Publication Collection Using BOC Sciences ProductsNews
BOC Sciences continues to add more publication items that used BOC Sciences products in their researches to its already existing collection.READ MORE
Sciformix Corporation Collaborates with Oracle Health SciencesNews
New collaboration enables faster and more informed drug safety decisions.READ MORE