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Small Molecule Promotes Removal of Excess Cholesterol

News   Nov 28, 2018 | Original story from eLife

 
Small Molecule Promotes Removal of Excess Cholesterol

A small molecule (shown here in pink) with the ability to increase 'good' (HDL) cholesterol in animal models binds to the membrane-binding domain of lecithin:cholesterol acyltransferase (LCAT; shown in teal). The site is remote from the active site of the enzyme but somehow enables the transfer of lipid substrates from HDL. Credit: Kelly Manthei and Stephanie King

 
 
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