Study Investigates Inherent Contamination in Deep Well Microplates
News Oct 21, 2014
A recent study by the Department of Chemistry at the University of Kent, UK provides a detailed analysis of deep well microplates and the significant levels of contamination found in more than 50% of the commercially available plates tested.
The study, following on from an earlier study in 2005, gives data on a large range of microplates from numerous manufacturers based in Europe, USA and China. Mass spectral data shows that persistent contamination from a range of compounds found in the raw polymer master batch continues to be evident in many of the microplates tested.
The effect of extractables leached out of the deep well plates identified in this report depends on the exact application for which the plate was designed but is highly likely to significantly affect their performance and contaminate samples stored in them.
The authors of the report conclude it is likely that a low grade polypropylene was used in the production of many of the microplates that leached extractables when tested. Such low grade polypropylene often contains flow modifier additives or “mould release agents” which will have been used to ease the manufacturing process and help free the moulded microplate from the mould respectively.
The solvent used for "extraction" of potential leachates in this study was methanol. As mass spectral testing was undertaken after only 24 hours, it is clear that samples do not have to be in these plates for very long before they can become contaminated.
Concept Life Sciences appoints New Group Programme Manager and US Head of SalesNews
Key leadership appointments support integration of the Group and expansion in the US market.READ MORE
Blood-vessel-on-a-chip Provides Insight into Novel Anti-Inflammatory Drug CandidateNews
Researchers have discovered that synthetic APC-mimicking small molecules called “parmodulins” provide anti-inflammatory and anti-thrombotic protection to endothelial cells on par with APC’s without interfering with normal blood clotting and coagulation, making them attractive new drug candidates.READ MORE
Brian Berridge Set to Manage National Toxicology ProgramNews
The National Toxicology Program (NTP) has named Brian Berridge, D.V.M., Ph.D., as its new Associate Director. Berridge, formerly of GlaxoSmithKline, will oversee day-to-day operations as NTP coordinates toxicology research and testing across nine different federal agencies.READ MORE