Sun Pharma Chooses FEI Solution for Nanoparticle Research at Advanced Centre in India
News Sep 30, 2008
FEI Company has announced the installation of a solution based upon FEI’s Tecnai™ Spirit cryo-transmission electron microscope (TEM) and three-dimensional (3D) tomography software at Sun Pharmaceutical Industries, Ltd., Mumbai, India.
Sun Pharmaceutical will use FEI’s 3D imaging solution for quality control of drug-loaded vesicles to speed up the development of new therapeutics.
“The cost of developing drugs and bringing new products to market is enormous and rising yearly; having access to accurate and timely information is essential for making decisions on compounds in our pipeline,” said Dr. Subhas Bhowmick, vice president formulation development, Sun Pharmaceutical.
“We will use the FEI 3D imaging solution to gain a better understanding of the behavior of the drug in the human body in an effort to develop therapeutics that not only are more effective, but also exhibit reduced side effects. The information will also help us to shorten the drug development process and bring new therapeutics to market faster,“ he added.
Cryo-TEM allows life science researchers to study biological systems in their native, hydrated state and obtain information about the particle structure and function. Other (non-cryo) microscopy and preparation techniques can damage the fragile biological sample and do not preserve the structure needed for 3D reconstruction information.
FEI’s tomography software allows for the system’s automation to acquire and process thousands of images unattended. FEI’s 3D imaging solution can also aid in the pharmaceutical production process. These new drug delivery techniques utilize labeled liposomes that are transferred directly to the site of interest and enable targeted delivery of drugs without harming healthy tissue.
New Chemical Synthesis Process: Synergy of Two Catalysts in One FlaskNews
Researchers report the one-step synthesis of a ketone from an aldehyde by the combination of thiazolium N-heterocyclic carbene and palladium/bisphosphine catalysts in one flask. The two catalysts function in a synergistic manner. This study is expected to lead to new synthesis processes of precursor compounds for medications.READ MORE
Nanotechnology Detects Molecular Biomarker for OsteoarthritisNews
For the first time, scientists have been able to measure a specific molecule indicative of osteoarthritis and a number of other inflammatory diseases using a newly developed technology. This preclinical study used a solid-state nanopore sensor as a tool for the analysis of hyaluronic acid.READ MORE
Synthesis of Drug-Like Molecules Simplified Using New Cross-Coupling MethodNews
Researchers have designed a new molecule-building method. The technique, described recently in the journal Science, paves the way toward other new chemical reactions and facilitates the synthesis of pharmaceutically-relevant molecules.READ MORE