SuperGen Announces Identification of new Class of Etk/Bmx Kinase Inhibitors at the AACR 100th Annual Meeting 2009
News Apr 23, 2009
SuperGen Inc. has announced as part of a series of presentations at the 100th Annual Meeting of the American Association for Cancer Research (AACR), that it has identified a new class of small molecules which successfully inhibit Etk/Bmx kinase in preclinical cancer models.
Entitled, “Targeting Etk/Bmx kinase with small molecule inhibitors,” the poster highlights data indicating that SuperGen lead compounds in this class inhibit the autophosphorylation of Etk, the activation of STAT3 downstream of EGF stimulation, and inhibit the colony formation of prostate and liver cancer cells lines in soft agar.
“SuperGen is committed to bringing first in class drugs into the clinic against cancer drug targets, and Etk/Bmx represents another one of these targets,” said Dr. David Bearss, SuperGen’s Chief Scientific Officer. “We are excited about selecting a clinical candidate for this program and think this program signifies another example of what our company and drug discovery technology can accomplish.”
New Chemical Synthesis Process: Synergy of Two Catalysts in One FlaskNews
Researchers report the one-step synthesis of a ketone from an aldehyde by the combination of thiazolium N-heterocyclic carbene and palladium/bisphosphine catalysts in one flask. The two catalysts function in a synergistic manner. This study is expected to lead to new synthesis processes of precursor compounds for medications.READ MORE
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