Take a Look at Some Recent Case Studies of Protein-Protein Interaction Drug Discovery
News Mar 24, 2006
Research and Markets has announced the addition of the Decision Resources report "Protein-Protein Interactions: Are They Now Druggable Targets?" to their offering.
This Decision Resources report discusses why protein-protein interactions are so hard to target, describe general strategies for targeting them, and present case studies of protein-protein interaction drug discovery.
It also describes projects of three major companies involved in this area and discusses the outlook for this field.
Researchers have been developing a body of science and technology to enable them to exploit protein-protein interactions as drug targets.
The toolkit of technologies aimed at addressing the major challenges in drug discovery for protein-protein interactions encompasses structure-based drug design, peptide-based technologies, combinatorial and medicinal chemistry, fragment-based screening, and whole-pathway cellular assays.
Recently, corporate and academic researchers have discovered several compounds that modulate protein-protein interactions.
The most advanced compounds in this field are thrombopoietin mimetics that arose from a collaboration between Ligand and GSK: eltrombopag (SB-497115) and SB-559448 are in Phase II and Phase I clinical trials, respectively.
Preclinical compounds targeting protein-protein interactions in development focus mainly on cancer.
Although research to discover small-molecule drugs that target protein-protein interactions is still at an early stage, accelerated activity in this area is expected as compounds move through clinical trials and as the science and technology base continues to develop.
The spatial and temporal dynamics of proteins or organelles plays a crucial role in controlling various cellular processes and in development of diseases. However, acute control of activity at distinct locations within a cell cannot be achieved. A new chemo-optogenetic method enables tunable, reversible, and rapid control of activity at multiple subcellular compartments within a living cell.
Scientists from the UNC School of Medicine discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet. The researchers also reported that the NLRP12 gene is underactive in people who are obese, making it a potential therapeutic target for treating obesity and diabetes.READ MORE