Tapestry Presents Data Supporting the Oral Bioavailability and Antitumor Activity of TPI 287

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Published: April 10, 2006

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Tapestry Pharmaceuticals, Inc. has presented data on its lead oncology drug candidate TPI 287 at the 97th Annual Meeting of the American Association for Cancer Research (AACR) in Washington, DC.

Data presented indicates that TPI 287 is orally bioavailable in rats and that oral dosing of TPI 287 has antitumor activity in a mouse xenograft model.

In addition, data were presented from in vitro transport assays which demonstrate that TPI 287 is not a substrate for drug efflux in the MDCKII-MDR monolayer system and that TPI 287 demonstrates increased potency in cell cytotoxicity assays with MDR 1+ and mutant tubulin expressing tumor cell lines when compared to paclitaxel.

A poster entitled "Oral Bioavailability and antitumor activity of TPI 287 - a new taxane analog with greater activity against tumor cells with demonstrated mutant tubulin," Abstract No. 493, by David L. Emerson, Carol Bell, Mark Jones, Barbara Schiemann and Gilles Tapolsky was presented Sunday, April 2, 2006 at 8:00 AM.

Drug Discovery

Drug Discovery

Tapestry Presents Data Supporting the Oral Bioavailability and Antitumor Activity of TPI 287