Tapestry Presents Data Supporting the Oral Bioavailability and Antitumor Activity of TPI 287
News Apr 10, 2006
Data presented indicates that TPI 287 is orally bioavailable in rats and that oral dosing of TPI 287 has antitumor activity in a mouse xenograft model.
In addition, data were presented from in vitro transport assays which demonstrate that TPI 287 is not a substrate for drug efflux in the MDCKII-MDR monolayer system and that TPI 287 demonstrates increased potency in cell cytotoxicity assays with MDR 1+ and mutant tubulin expressing tumor cell lines when compared to paclitaxel.
A poster entitled "Oral Bioavailability and antitumor activity of TPI 287 - a new taxane analog with greater activity against tumor cells with demonstrated mutant tubulin," Abstract No. 493, by David L. Emerson, Carol Bell, Mark Jones, Barbara Schiemann and Gilles Tapolsky was presented Sunday, April 2, 2006 at 8:00 AM.
Key Ingredient in Diabetes Drug Modified to Improve Side EffectsNews
Improved medications for Type 2 diabetes are one step closer thanks to a new discovery reported this week. By modifying the key ingredient in current diabetes drugs, the researchers produced a compound that was effective for hyperglycemia in animal trials, yet without the most problematic side effects of current drugs.READ MORE
Chili Pepper Derived Anti-Obesity Drug Shows Promise in Animal TrialsNews
A novel drug based on capsaicin, the compound that gives chili peppers their spicy burn, caused long term weight loss and improved metabolic health in mice eating a high fat diet.READ MORE
5th edition of the International Conference Clinical Oncology and Molecular Diagnostics
Jun 17 - Jun 18, 2019