Tarantula Venom Holds Hope for New Painkillers
News Feb 17, 2014
The findings, reported in the March 3 issue of the journal Current Biology, show the new screening method used by the scientists has the potential to search millions of different spider toxins for safe pain-killing drugs and therapies.
The researchers note that they tested the spider toxins on only one of a dozen suspected human pain channels.
“The likelihood is that within the vast diversity of spider toxins we will find others that are active against other channels important for pain,” said Michael Nitabach, associate professor of cellular and molecular physiology and of genetics, and senior author of the paper.
The researchers screened the toxins from a variety of tarantula species to find one that blocked TRPA1, an ion channel on the surface of pain-sensing neurons that is implicated in inflammation and neuropathic pain.
In a process dubbed toxineering by the Yale researchers, the team generated another small library of mutated versions of the tarantula toxin to find one that blocked TRPA1 but had no effect on activity of other channels on the surface of neurons.
“The beauty of the system is we can also screen engineered toxins not found in nature, and identify higher-potency and more specific molecular variants that lack deleterious effects on essential nerve functions,’’ Nitabach said.
His lab plans to ramp up efforts to test tens of thousands of new toxins for similar biological activity against pain-sensing neurons.
Junhong Gui and Boyi Liu of Yale are co-lead authors of the study, which was funded by the National Institutes of Health.
Bioinformatics to Help Understand Intrinsically Disordered ProteinsNews
Over the last several decades, scientists have sequenced 85 million unique proteins, structured and unstructured alike, but still don’t know what the vast majority of these proteins do.READ MORE
Ingestible Drug-Delivery Materials May Improve Patient Treatment ComplianceNews
Hydrogel-based capsules could expand and reside in the GI tract for days, slowly releasing medication.READ MORE
Protein Discovery Could Lead to Better Diagnosis of StressNews
Researchers have found a protein that is present in people while they are in stressful situations. The discovery could lead to identifying new ways to predict, diagnose and treat stress.READ MORE
Comments | 0 ADD COMMENT
6th Edition of International Conference on Pharmacognosy and Medicinal Plants
Apr 16 - Apr 17, 2018
International Conference and Exhibition on Nanomedicine and Nanotechnology
Nov 23 - Nov 24, 2017
11th Edition of International Conference on Proteomics 2018
Mar 22 - Mar 23, 2018