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Subscribe for FREEHirsch and her team are currently working on the further development of the new molecules. To this end, they are planning to collaborate closely with the planned excellence cluster nextAID³, in which unexplored targets such as IspD will also play an important role. The next steps include efficacy studies in bacteria and the optimization of efficacy and other pharmaceutical parameters.
Reference: Willocx D, D’Auria L, Walsh D, et al. Fragment discovery by X-ray crystallographic screening targeting the CTP binding site of Pseudomonas aeruginosa IspD. Angewandte Chemie Int Ed. 2024:e202414615. doi: 10.1002/anie.202414615
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