Tecan and Pion Expand Collaboration to Develop Automated Drug Screening Solutions
News Jul 16, 2009
Following the launch of the manual assay systems for permeability and solubility, Tecan AG and pION INC have developed automated solutions for drug permeability and solubility screening.
The new automated application provides scalability from an upgradeable, entry-level manual system, to a fully automated system with medium or high throughput, according to changing requirements.
pION’s Double-Sink™ parallel artificial membrane permeability assay (PAMPA), a compound-sparing technique that helps to identify the most promising leads well in advance of cell-based methods, has been integrated with Tecan’s Freedom EVO® platform and Infinite® M200 plate reader in the PAMPA Evolution™.
The system offers enhanced walkaway time and high throughput for fully automated processing of permeability assays, while automated miniaturized shake-flask solubility assays can be done with the similarly configured µSOL Evolution™.
The flexibility of the Freedom EVO workstation also allows the same instrument to perform both permeability and solubility assays in a combined set-up, as well as other ADME assays.
The advanced Quad4 Monochromators™ technology in the Infinite M200 provides sensitivity and an optional MultiChannel Arm™ 96 in the Freedom EVO platform increases throughput with sample transfers.
Catalysis is common in many industries such as pharmaceutical, specialty chemicals, agriculture, polymer and over 90% of chemicals are made from catalytic processes. Researchers have reported an asymmetric reaction that uses a cationic (positively charged) catalyst to convert racemic (equal mixture of two enantiomers) substrates to asymmetric product via an intriguing reaction route,READ MORE