We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.


The Benefits of Constructing Leads from Fragment Hits

Want a FREE PDF version of this news story?

Complete the form below and we will email you a PDF version of "The Benefits of Constructing Leads from Fragment Hits"

Listen with
Register for free to listen to this article
Thank you. Listen to this article using the player above.
Read time:

'Fragments' refer to particularly small molecular starting points in medicinal chemistry. The small size of fragments requires adapted techniques for their screening and subsequent elaboration. The detection of the weak binding affinity of fragments for their target, and associated screening issues, have been debated at length. Since it is now clear that fragments can be developed into clinical candidates, the discussion is shifting to the design of good-quality lead compounds from fragment hits.

The article is published online in Future Science and is free to access.