The Concise Guide to Pharmacology: Simplifying Drug Discovery
The Concise Guide to PHARMACOLOGY 2017/18 is now available in the British Journal of Pharmacology. Published by Wiley on behalf of the British Pharmacological Society, the 440 page guide includes overviews of key properties for close to 1,700 human drug targets, identifies 3,500 ligands including more than 2,400 synthetic organic molecules and over 50 antibodies. Over 4,000 interactions between ligands and targets are quantified, allowing researchers to assess the potency of these interactions.
This open access knowledge-base of major drug targets is completely linked and divided into eight major areas of research focus:
• G protein-coupled receptors
• Ligand-gated ion channels
• Voltage-gated ion channels
• Other ion channels
• Nuclear hormone receptors
• Catalytic receptors
“As a pharmacologist, being able to access freely information on current human drug targets is vital to discovering new therapeutics,” said Steve Alexander, Associate Professor of Molecular Pharmacology, Faculty of Medicine & Health Sciences at the University of Nottingham and Lead Editor of the Concise Guide.
The Concise Guide provides an authoritative voice on nomenclature of these pharmacological targets through close links with NC-IUPHAR. It offers summary information on the best available pharmacological tools, alongside key references and suggestions for further reading.
“The Concise Guide to PHARMACOLOGY is the drug discovery researchers’ bible,” said Amrita Ahluwalia, Co-Director, The William Harvey Research Institute, Professor of Vascular Pharmacology at Barts & The London School of Medicine & Dentistry, and Editor-in-Chief of the British Journal of Pharmacology. “We are pleased to once again make the Concise Guide freely available to our colleagues around the globe at www.guidetopharmacology.org/concise.”
This edition of the Concise Guide was compiled with the help of over 150 collaborators representing industry and academia from 22 countries across four continents. The British Pharmacological Society would like to thank the Universities of Cambridge, Edinburgh, Nottingham in the UK, and Monash, Australia for their contributions to updating the Concise Guide to PHARMACOLOGY.
This article has been republished from materials provided by Wiley. Note: material may have been edited for length and content. For further information, please contact the cited source.
H7N9 Influenza Vaccine Clinical Trials CommenceNews
Two new clinical trials testing an experimental vaccine to prevent influenza caused by an H7N9 influenza virus are now enrolling volunteers at sites across the United States. The Phase 2 studies will test different dosages of the inactivated influenza vaccine candidate as well as different vaccination schedules. The studies also will evaluate whether an adjuvant boosts the immune responses of people receiving the vaccine.
Researchers Fine-Tune Computer-Assisted Drug Repositioning Process to Treat Rare DiseasesNews
Researchers at the LSU Computational Systems Biology group have developed a sophisticated and systematic way to identify existing drugs that can be repositioned to treat a rare disease or condition.READ MORE
Study Extends Potential of Personalized Cell-based ImmunotherapiesNews
New methods developed for the study could be applied to devise personalized, cell-based immunotherapies for epithelial ovarian cancer or other types of tumorsREAD MORE