The Potential Medical Use of Ant Honey
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Scientists have discovered the honey produced by Australian ants possesses unique anti-microbial activity against bacteria and fungi that could make the liquid useful medicinally.
The research, published today in PeerJ, was led by Andrew Dong and Dr Kenya Fernandes from the University of Sydney’s Carter Lab, which is led by Professor Dee Carter from the School of Life and Environmental Sciences and Sydney Institute for Infectious Diseases.
The team studied the Australian honeypot ant, Camponotus inflatus, which is found throughout desert areas mainly in Western Australia and the Northern Territory.
Among their colonies are a class of overfed workers that are stuffed with nectar and sugary substances by other worker ants, causing their abdomens to inflate with honey and take on a translucent, amber appearance.
These ants effectively become immobile vending machines for their colony, regurgitating honey when other food options are scarce.
Danny Ulrich from the Tjupan language group, who runs honeypot ant tours in Kalgoorlie, helped the researchers track down specimens for their study.
“For our people, honey ants are more than just a food source. Digging for them is a very enjoyable way of life, and a way of bringing the family together,” Mr Ulrich said.
“Our people have been enjoying sweet honey ants for thousands of years.
“As for its medicinal use, we use it for sore throats and sometimes as a topical ointment to help keep infections at bay.”
The researchers said their study marks the first time that ant honey has been investigated for its medicinal properties.
“I have long been fascinated by the honeypot ant and its amazing way of producing and storing honey,” Mr Dong said.
“Given the medicinal use of the honey by Indigenous people, I wondered if it might have unique antimicrobial characteristics.”
The scientists have confirmed that ant honey has a quite different mechanism of action compared with Manuka honey, which is well established as a topical treatment for wounds and skin infections.
“Our research shows that honeypot ant honey possesses a distinctive effect that sets it apart from other types of honey,” Dr Fernandes said.
“This discovery means that honeypot ant honey could contain compounds with substantial antimicrobial power; identifying these could provide us with starting points for developing new and different types of antibiotics.”
Honeypot ants have been used medicinally by First Nations people for thousands of years, including for the treatment of colds and sore throats. But now Western science is catching up with their traditions.
“This study demonstrates that honeypot ant honey has unique antimicrobial characteristics that validate its therapeutic use by Indigenous peoples,” Professor Carter said.
“Taking something that has been honed by evolution to work in nature and then applying this to human health is a great way to come up with therapeutic strategies.”
The researchers found the ant’s honey is effective against Staphylococcus aureus, a bacterium commonly known as golden staph. The bacteria colonise on the skin and nose of people, but if they enter through a cut, they can cause infection such as boils and sores or, in serious cases, death.
They also found ant honey is potent against two species of fungi, Aspergillus and Cryptococcus. Both fungi can be found in soil and this ability to inhibit them probably evolved to prevent ant colonies from being invaded by fungi. These fungi can also cause serious infection in people with suppressed immune systems.
Reference: Dong A, Cokcetin N, Carter DA, Fernandes KE. Unique antimicrobial activity in honey from the Australian Honeypot Ant (Camponotus inflatus). PeerJ. 2023. doi: 10.7717/peerj.15645
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