Total Synthesis and Complete Structural Assignment of Thiocillin I

Researchers at the Crick and Imperial College London have generated malaria parasites resistant to a promising new class of candidate antimalarial drugs. By analyzing the structural changes behind the resistance, they identified novel compounds that were immune to this mechanism of resistance.

Nearly ninety per cent of all cancer patient deaths are due to metastasis. A study shows that a process that allows the cells to metastasise is aided by the synthesis of new ribosomes, the cell components in which proteins are produced.

Structure-based drug design revealed that a compound previously investigated for the treatment of head-and-neck cancer could function as a lead compound for the development of drugs to treat hepatitis A virus infection.