Xceleron and Organon Sign Microdose Study Agreement
News Sep 11, 2007
Xceleron Ltd announced collaboration with Organon, the human healthcare business unit of Akzo Nobel, on a three-compound human microdose study focusing on candidate selection for further clinical development.
Xceleron says that it has been selected by Organon on the basis of fast and cost-effective delivery of human information that will enable them to make better choices in early drug development.
The three selected drug candidates are all compounds that have emerged from Organon’s gynaecological research and development activities. The purpose of the human microdose study is to assess all important pharmacokinetic properties of the compounds whilst confirming the scalability of the microdose to pharmacological dose for these compounds.
Xceleron will use its ultra-sensitive Accelerator Mass Spectrometry analytical technology to determine human plasma concentrations after microgram administration of the various drug candidates.
“Increasingly, leading pharmaceutical companies are adopting Xceleron’s new drug development strategies to maximise data on compounds in the exploratory clinical development phase” observed Xceleron’s founder and CEO Professor Colin Garner.
“We are delighted that Organon has further demonstrated its willingness to adopt innovative approaches to drug development and are proud to add them to Xceleron’s rapidly growing, international portfolio of human microdose supporters”, he added.
David Nicholson, Executive Vice-President Research & Development of Organon commented: “given previous positive experiences with Xceleron and its enabling technology we have commissioned this microdose study to examine important pharmacokinetic parameters in humans in order to aid confirmation of the best candidate for further development”.
Commenting on the value of the innovative human microdose approach he added: “the most compelling reason for using human microdosing is the speed with which we can gain results from human studies to make pivotal decisions”.
New Partnership to Provide Bioanalytical and DMPK ServicesNews
Concept Life Sciences, the integrated drug discovery, development and analytical services company, and Alderley Analytical, bioanalytical Contract Research Organisation (CRO), today announced they have signed a partnership agreement to provide high-value bioanalytical and DMPK study services.