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Yin and Yang in Medicinal Chemistry: What does Drug-Likeness Mean?
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So what distinguishes a drug from a poison? It is the dose, stupid! Medicinal chemistry is the art of discovering molecules that display a therapeutic window, that is, a separation between the efficacious and the toxic doses, which allows a safe administration to cure a disease.
This editorial, written by Ricardo Macarron and Juan L Luengo of GlaxoSmithKline, is published in Future Science and is free to access.
