Yin and Yang in Medicinal Chemistry: What does Drug-Likeness Mean?
News May 11, 2011
So what distinguishes a drug from a poison? It is the dose, stupid! Medicinal chemistry is the art of discovering molecules that display a therapeutic window, that is, a separation between the efficacious and the toxic doses, which allows a safe administration to cure a disease.
This editorial, written by Ricardo Macarron and Juan L Luengo of GlaxoSmithKline, is published in Future Science and is free to access.
The ideal drug is one that only affects the exact cells and neurons it is designed to treat, without unwanted side effects. This concept is especially important when treating the delicate and complex human brain. Now, scientists have revealed a mechanism that could lead to this kind of long-sought specificity for treatments of strokes and seizures.READ MORE