Latest Posters
Poster
High Throughput Rheological Characterization of Small Volume Biopharmaceutical Formulations
Importance of assessing viscosity fingerprints of small molecules.
Poster
Getting Ready For The 21st Century Photochemistry - Teaming Up Continuous Flow And LED
Corning has developed a scalable photo flow reactor with an optimized LED lighting(3). The presented experimental data will demonstrate the various benefits of performing photo chemistry in a continuous way, especially the simplicity of scaling up and enormous energy savings, which are today the main stopper for industrial application.
Poster
Applications of chemically modified synthetic guide RNA for CRISPR-Cas9 genome editing
Our results indicate that MS modifications are required for experiments with co-electroporation of Cas9 mRNA and synthetic gRNA, yet have no impact on editing efficiency when delivered with lipid-based transfection reagents.
Poster
Novel lead optimization strategy of BACE I inhibitors for the treatment of Alzheimer’s disease by Quantitative Structure-Activity Relationship (QSAR) and Physiologically-Based Pharmacokinetics (PBPK) modeling
In this study, we introduce an innovative in silico-based high throughput lead optimization strategy with QSAR and PBPK modelings using StarDrop™, ADMET predictor® and GastroPlus®.
Poster
Inecalcitol Stimulates CD38 Expression in Multiple Myeloma and Acute Myeloid Leukemia Cell Lines
Inecalcitol is a vitamin D receptor agonist currently in Phase II clinical trial in AML (acute myeloid leukemia). Inecalcitol increases the expression of CD38 at the surface of 5 multiple myeloma cell lines; therefore, inecalcitol could potentiate the clinical response of MM patients to a therapeutic anti-CD38 antibody
Inecalcitol induces the expression of the CD38 antigen at the surface of 4 AML cell lines; thus, inecalcitol could render AML patients sensitive to a therapeutic anti-CD38.
Inecalcitol induces the expression of the CD38 antigen at the surface of 4 AML cell lines; thus, inecalcitol could render AML patients sensitive to a therapeutic anti-CD38.
Poster
Strategies for Improving RNAi Screening Success: Using a Ubiquitin-EGFP Assay to Identify Druggable Genes Required for Proteasome Function
This poster describes the approaches used to ensure effective delivery of siRNA molecules and to identify robust siRNA controls. It also provides the strategies used to validate compatibility of the RNAi automation platform with the phenotype being analyzed.
Poster
Optimized Workflow for Single Cell Copy Number Profiling Using High Resolution Oligo CGH Arrays
Here we describe GenetiSure Pre-Screen, a same day, cost-effective, analysis workflow that combines whole genome amplification (WGA) with copy number (CN) profiling using high-resolution oligo CGH microarrays.
Poster
Functional Analysis of RAD51B and RAD23B SNPs using Circular Chromosome Conformation Capture (4C) in Human Prostate Cell Lines
The aim of this study is to understand the mechanism behind the association between single nucleotide polymorphisms (SNPs), lying in non-coding regions near or within RAD51B and RAD23B, and prostate cancer risk by analysing their interactions with the whole genome using Circular Chromosome Conformation Capture (4C).
Poster
Multiplexed Cell- and Bead-based Assays in a No-wash Format for Biologics Screening and Characterization
Here we present the results generated from multiplexed no-wash protocols using TTP Labtech’s mirrorball, a laser scanning cytometer.
Poster
Platform Agnostic Data Processing Routine for Targeted and Untargeted Metabolite Identification in Drug Discovery
A discussion of a new informatics solution that addresses common challenges in metabolite identification and characterization--from LC/MS data processing and metabolites prediction to reporting and databasing of assembled biotransformation knowledge.
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