Latest Posters
Poster
Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells: High Throughput and High Content Assessment of Cardiac Toxicity and Drug Efficacy by Monitoring Cytosolic Free Calcium Transients
Introduction of selected, pure human cardiomyocytes derived from induced pluripotent stem cell (hiPSCM) into a calcium transient imaging high throughput screening (HTS) assay to assess cardiotoxicity and drug efficacies.
Poster
Early Immunogenicity Risk Mitigation
The ability of a drug candidate to induce an unwanted immune response can be a significant hurdle during drug development and a reason for product failures. Unwanted immunogenicity can cause loss of efficacy, altered pharmacodynamics and stability problems. .
Poster
Developing Functional Monoclonal Antibodies for Beta-3 Adrenergic Receptor
Our preliminary data showed that several mAb clones specific ally bound to the receptor while increasing the receptor function by acting as agonists.
Poster
Novel Gpr39 Agonists: Correlation Of Binding Affinity Using Label-Free Back-Scattering Interferometry With Potency In Functional Assays
We describe the application of back-scattering interferometry (BSI) to the characterization of small molecule ligand binding to human GPR39 (a GPCR targeted for type-2 diabetes therapy) overexpressed in crude membrane fractions in free solution, including how BSI-derived affinity and functional assay-derived potency correlate for compounds of varying scaffolds.
Poster
Metabolite Profiling Using Human Hepatocyte Co-cultures and UHPLC-QTOF-MS with Data Independent MS/MS
Purpose
To investigate a high throughput workflow for metabolite profiling using a novel human in vitro system and advanced UHPLC-MS/MS techniques to accurately predict human metabolite profile in vivo.
To investigate a high throughput workflow for metabolite profiling using a novel human in vitro system and advanced UHPLC-MS/MS techniques to accurately predict human metabolite profile in vivo.
Poster
In Vitro Species Comparison Using Long-Term Hepatocyte Co-Cultures Model and Highly Sensitive UHPLC-QTOF-MS with SWATH Analysis
Purpose: To develop a reliable, quicker, and cost-saving in vitro method to accurately predict major human metabolite profile in vivo and to de-risk disproportional or unique human metabolites before a drug candidate nomination
Poster
Metabolic Stability Assay Using Human Hepatocyte Co-cultures and Integrated Qualitative/Quantitative High Resolution Mass Spectrometry
Purpose: To investigate Sequential Window Acquisition of all Theoretical fragment ion spectra (SWATH™) based integrated qualitative and quantitative (qual/quant) assay for simultaneous metabolic stability and metabolite profiling assessments.
Poster
TOXICITY OF SELECTED BIOACTIVATED COMPOUNDS IN PRIMARY RAT HEPATOCYTES CULTURED IN MICROPATTERNED CO-CULTURES
Drug Induced Liver Injury (DILI) modeled in a novel co-culture liver model. Here, we assess the bioactivation and cytotoxicity of acetaminophen (APAP) and other compounds in the 96-well rat MPCC.
Poster
Rapid Quantification of Proteins in Complex Matrices using the DeNovix DS11 Microvolume Spectrophotometer
In this poster, we will introduce the DeNovix DS-11 as the next generation in microvolume spectrophotometry.
Poster
Mixtures Analysis of Complex Mixtures
We describe an NMR method to quantify mixture components in wine, edible oils, etc. The method is fully customizable, and amenable to high throughput operation.
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