Latest Posters
Poster
Random Homozygous Gene Perturbation (RHGP) as a Tool for Target Discovery and Validation
Random homozygous gene perturbation (RHGP) can identify and validate any host (cellular) gene target that directly causes a desired phenotype without requiring prior knowledge of the target. The central feature of RHGP is a unique lentiviral-based genetic element, known as a gene search vector (GSV) designed to interrogate the entire genome and identify target genes that cause the phenotype of interest.
Poster
Finally, a User-Friendly Way of Computing and Presenting Individual Group Contributions to Polyprotic Ionization of Drugs
It is tempting to “assign” the macroscopic ionization constants (apparent pKa‘s obtained from titration experiments) of molecules to specific ionizable groups; however, this is strictly appropriate only in the case of monoprotic molecules.
Poster
Novel Antimalarial Drug Candidates Generated In Silico by Analysis of Public HTS Data
This research aims to provide proof-in-principle that in silico tools could be applied to public data so as to efficiently identify active chemistry with good ADMET properties.
Poster
Development of an Automated Platform for HT Cloning and Expression
Biomolecular protocols covering the whole cloning process were implemented in liquid handler robots. When compared to the manual approach, it was found that automation significantly speeds up HT cloning.
Poster
Physiologically-based pharmacokinetic (PBPK) models for prediction of saquinavir effect on midazolam pharmacodynamics
Purpose: To predict the drug-drug interaction effect of saquinavir on midazolam pharmacodynamics (PD).
Poster
Physiologically-based pharmacokinetic (PBPK) model for prediction of midazolam pharmacokinetics after intranasal administration in children
Study predicts midazolam absorption and pharmacokinetics (PK) after intranasal (i.n.) administration in young children.
Poster
Modeling Drug Disposition of Timolol in Ocular Tissues of Rabbit following Topical Eye Drops
A serious disadvantage of ocular timolol therapy is the amount of drug getting into systemic circulation that adversely affects vital organ functions in elderly patients.
Poster
Transporter-based In Vitro-In Vivo Extrapolation (IVIVE)
Mechanistic analysis of in vitro measurements to obtain values of kinetic parameters for drug interactions with transporters, as well as for passive diffusion through cell membranes.
Poster
Metal Polymers, A Glue to Immobilise Proteins Onto Synthetic Surfaces
The main objective of this work was to develop a surface chemistry which maintains protein function and orientation per unit surface area, regardless of the surface used.
Poster
Analyzing Molecular Polar Surface Descriptors to Predict Blood-Brain Barrier Permeation
Permeation of active drugs across the vascular brain endothelium into the central nervous system (CNS) is controlled by the blood-brain barrier (BBB). Some molecular quantities like polar surface (PS) descriptors are of key interest to medicinal chemists to predict the BBB permeation fate for different drug-like chemical compounds.
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