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Latest Posters

Poster

Computer simulation to support mammography physics education

We have designed and implemented a software tool called MX-RayCalc, that simulates mammography X-ray production and transport, to create an interactive environment to support education in either an instructor-led or self-directed environments.
Poster

Applying QbD in Process and Impurity Control Strategy Development

Manage impurity data in pharmaceutical development more effectively in a single informatics solution. Assemble all relevant analytical data with chemical information for real-time access to project information by the entire team.
Poster

Lymphatic Wall Remodeling with Systemic and Tissue-Associated Inflammation in Obese Zucker Rats

Obesity Leads to Lymphatic Wall Remodeling and Systemic and Tissue-Associated Inflammation in Zucker Rats
Poster

Anti-CelTOS Transmission Blocking Activity in vivo and in vitro against P. falciparum by Epitope-specific Monoclonal Antibodies

The presence of CelTOS mAb significantly inhibited oocyst development in mosquitoes in both in vivo and in vitro assays. Importantly, the experimental results with an innovative in vivo humanized mouse model confirmed that circulating anti-CelTOS antibody effectively inhibits P. falciparum ookinete development to oocyst in mosquitoes. These results support the development of CelTOS as a transmission blocking vaccine.
Poster

A Computational Model of Mood and Future Prospects

Mood disorders are characterized by changes in reaction to positive events, but studies examining mood in gambling have suggested these changes may not be different from control. Interrogating mood changes with a computational model may give insight into disorders like depression.
Poster

Knockout of microRNAs Using the CRISPR-Cas9 System with Paired Synthetic crRNAs

We utilized paired synthetic crRNAs coupled with our synthetic tracrRNA in cells transduced with lentiviral Cas9 to perform a functional knockout on hsa-miR-221. This three-part system (crRNA, tracrRNA and Cas9) has demonstrated efficient gene editing when used with only one guide RNA, but the goal was to use two crRNAs to remove the entire stem-loop.
Poster

Analysis of Extract Drying Criteria for Oil & Grease Method 1664A/B

Analysis of Extract Drying Criteria for Oil & Grease Method 1664A/B
Poster

New Biotransformation Prediction Engine Integrated into a Metabolite Identification Solution

Here we present a new prediction algorithm that determines the likelihood of biotransformation reactions, and subsequent metabolite identification, within an automated processing routine.
Poster

A New Method for Analyzing MSe/All Ions Fragmentation in Xenobiotic Metabolism Studies

During early drug discovery, the study of metabolism plays an essential role in determining which drug candidates move forward into development and later stages. As an alternative to traditional Data Dependent Acquisition (DDA), the use of MSE/All Ions Fragmentation (AIF) has become common in metabolite identification workflows for the analysis of metabolic hot spots. Here we present a solution for analysis of MSE/AlF in metID studies.
Poster

Histone Deacetylase 6 (HDAC6) As A Therapeutic Target in Chronic Lymphocytic Leukemia

This study investigates the role of histone deacetylase 6 (HDAC6) in chronic lymphocytic leukemia and establishes it as a novel therapeutic target for the treatment of this disease.
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