Latest Posters
Poster
CiPA Phase 2 Study: validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluation
These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.
Poster
Inhibiting CK2α from Outside the Active Site
Here we report the creation and characterization of a unique inhibitor of CK2a that targets a novel cryptic pocket and was developed using fragment-based methods.
Poster
MHV68 Infection in a Novel rag2 F62L/F62L Mouse Model Based on a Patient with CID-G/AI Phenotype
MHV-68 infection in our rag2 mouse model induced increased antibody responses to virus and self and inflammatory disease in end organs. Major mechanism of inflammatory infiltrates and autoantibody generation is yet to be determined
Poster
A luminescent solar concentrator-based photomicroreactor for energy efficient continuous-flow photocatalysis
The Luminescent Solar ConcentratorPhotomicroreactor
(LSC-PM) is an innovative device
for solar-powered continuous-flow photochemistry.
(LSC-PM) is an innovative device
for solar-powered continuous-flow photochemistry.
Poster
Design of a modularized, intensified milli-reactor for production scale
Results of a model based design of an exemplary chemical reaction in a production scale Miprowa® are presented, allowing for a considerable evaluation and classification of the reactor’s performance.
Poster
Monitoring Cell Health in Real-time / Time-lapse Cell-based Assays
The purpose here is to validate a novel far-red DNA binding viability probe, DRAQ7™, in real-time cell based assays for 2-D and 3-D models.
Poster
GALAS Modeling Methodology Applications In The Prediction Of Drug Metabolism Related Properties
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task and is performed only at the later phases of drug development. Therefore the possibility to predict possible sites of human liver microsomal (HLM) metabolism using in silico techniques would be a very attractive feature for any medicinal chemist.
Poster
Pharmacological Ascorbic Acid and Hyperbaric Oxygen Therapy Target Tumor Cell Metabolism via an Oxidative Stress Mechanism
This data indicates that AA exhibits anti-cancer effects in vitro through an OxS mechanism and that HBOT can enhance this therapeutic effect.
Poster
An Antitumor Antibody Response to Attenuate Metastatic Melanoma in a Murine Model
These preliminary results show antitumor activity of adoptive cell transfer of MHC class mismatched CD4(+) T-cells. The finding of reduced numbers of pulmonary metastases correlates with increased serum anti-OVA IgG and increased germinal center development in the spleen.
Poster
Activation of PTEN lipid phosphatase function in lung cancer
We have discovered novel small molecule compounds that directly induce PTEN function and antagonize PI3K/AKT pathway activity in lung cancer cells.
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