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The aim of this study was to establish clonal cell lines stably expressing a channelrhodopsin variant and measure membrane potential changes with a fluorescent dye induced by repetitive light-stimulations in a 96-well plate on a kinetic plate reader FDSS 7000EX.

This study reports on the quantitative analysis of the diffusion and localization of a targeted drug delivery system (DDS) consisting of fluorescent labeled 0.01 µM paclitaxel-BODIPY 564/570 encapsulated in non-ionic surfactant vesicles embedded in a thermosensitive cross-linked chitosan hydrogel.

An increase in phosphorylation of tau (hyper phosphorylation) leads to aggregation of the protein resulting in neurofibrillary tangles, a pathological hallmark associated with Alzheimer’s disease (AD). The identification of pharmacological agents that can help decrease levels of phosphorylated tau would be advantageous. Recent work in our laboratory has found that the molecule hexachlorophene can regulate levels of tau in cellular models.

Both oxidative stress and inflammation are involved in the progression of many neurodegenerative diseases, therefore, we examined the potential for AXT to reduced neurotoxicity in a toxic model of PD in mice. Here, we show that administration of algae derived AXT mitigated MPTP induced dopamine cell death.

Electrophiles can bind through reversible or irreversible reactions based on the structure of the compound. Here, patch clamp techniques and calcium imaging have been used to characterize human TRPA1 (hTRPA1) channel activity (expressed in HEK293 cells) in the presence of reversible and irreversible electrophiles

In this experiment, we sought to determine the function of hypusinated eIF5a in relation to TDP-43 pathology in nuclear and cytoplasmic compartments under cellular stress.

Profiling of inflammatory cytokines, receptor and kinases in WT and TDP-43 overexpressing mice.

The Luminescent Solar ConcentratorPhotomicroreactor (LSC-PM) is an innovative device for solar-powered continuous-flow photochemistry. It is constituted by an LSC lightguide that harvests solar photons and delivers them downshifted to the embedded microflow reactor.

Investigation into the most common ring system and substitution patterns in the recent medicinal chemistry literature, as derived from the ChEMBL database.

The human immune system is comprised of a complex network of immune checkpoint receptors that are promising new immunotherapy targets for the treatment of a variety of diseases including cancer and autoimmune-mediated disorders.