A Robust High Throughput Physicochemical Screen for Phospholipidosis
Abstract
Phospholipidosis (PLD), accumulation of phospholipids in tissues such as lungs, kidneys and liver, has gained increasing attention, particularly concerning drugs intended for long term usage. The poster presents a simple HT physicochemical screen, predicting PLD in real-time by surface activity profiling (using Kibron Delta-8 analyzer). The results are equal or better than derived from a cell based assay, throughput is up 450 compounds/24 hrs and drug consumption < 1 mg/compound.
Phospholipidosis (PLD), accumulation of phospholipids in tissues such as lungs, kidneys and liver, has gained increasing attention, particularly concerning drugs intended for long term usage. The poster presents a simple HT physicochemical screen, predicting PLD in real-time by surface activity profiling (using Kibron Delta-8 analyzer). The results are equal or better than derived from a cell based assay, throughput is up 450 compounds/24 hrs and drug consumption < 1 mg/compound.
