A Walk-Up ADME Testing System for Medicinal Chemists and Pharmacologists
Poster Feb 08, 2008
Muhammad Alimuddina, Martin Peacock, Russell Dahl, Omar Jina, and Paul Oakley
VivADME was born with the fusion of a problem and a solution: recognition by a Medicinal Chemist that ADME data took too long to obtain, and, the realization that microfluidic tools could address the problem. The vivADME microfluidics solution means that ADME profiling can be performed in minutes with microgram-scale samples in a walk-up system with a very low cost per sample. Examples are given for log D determinations, Liver Microsomal Stability and Plasma Stability. Log D measured by the microfluidics method was compared to the traditional shaken-flask method on 28 drug-like and other molecules and gave a correlation R2 = 0.9751. Rapidly obtained VivADME results for Microsomal Stability and Plasma Stability correlate well with more labour-intensive ADME results obtained using standard protocols.
CiPA Phase 2 Study: validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluationPoster
These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.READ MORE
A luminescent solar concentrator-based photomicroreactor for energy efficient continuous-flow photocatalysisPoster
The Luminescent Solar ConcentratorPhotomicroreactor
(LSC-PM) is an innovative device
for solar-powered continuous-flow photochemistry.