Application of Solid Phase Micro Extraction (SPME) and On‐Fiber Derivatization to Detect Precursors of Biomolecules in the study of Proto‐metabolism

In the studies of origins of life, plausible synthetic reaction pathways to form biological relevant molecules, or building blocks of proto‐bilayer lipids, protein, RNA, and DNA in the primitive environment have been investigated intensively. We are focusing on studying syntheses of primitive molecular set, including sugar, amino acid, and their analogues, which were selected by further functional and informational constrains.
Researchers hope to detect those targets, even they were ultra‐trace comparing to major components (source molecules and undefined byproducts). Analytical point of the views, it is the worst situation.