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Bioluminescent Approaches for In Vitro ADMET
Poster

Bioluminescent Approaches for In Vitro ADMET

Bioluminescent Approaches for In Vitro ADMET
Poster

Bioluminescent Approaches for In Vitro ADMET

Bioluminescent ADMET assays couple targets of interest to the photon emitting reaction of firefly luciferase. Multiplexed cell-based assays measure compound cytotoxicity and induction of P450 transcription and enzyme activity. Cell-free membrane assays measure P450 or monoamine oxidase enzyme activities and their inhibition by test compounds. Assay features include insensitivity to interference from fluorescent analytes, low intrinsic backgrounds, high sensitive and a large dynamic range for robust, high throughput applications.
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