Colony Forming Cell (CFC) Assays Predict for Increased Clinical Neutrophenia with Combination Therapies
Poster May 07, 2013
Dos Santos G, Mergaert A and Clarke E.
Combination therapies are being increasingly employed to treat diseases where single agents do not have the desired clinical benefit. There are a number of publications that cite the benefit of combination therapy over monotherapy in preventing disease progression.
Assessment of Oral LISPRO Treatment in Ameliorating Amyloid and Tau Pathology in Transgenic Alzheimer’s Mice ModelPoster
Ionic co-crystals of lithium salicylate with organic proline (LISPRO) showed better safety and pharmacokinetic profile of lithium in plasma and brain of wild-type and transgenic Alzheimer mice model compared to lithium salts.READ MORE
CiPA Phase 2 Study: validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluationPoster
These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.READ MORE
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