Communicating Drug Discovery Data Efficiently and Effectively
Poster Feb 01, 2007
Jonathan Davies and Andrew Lemon
Drug discovery generates vast amounts of multidisciplinary data which needs to be captured, consistently organized and shared effectively across an organization.
In this poster, we present IDBS’ ActivityBase™ — a single, integrated framework that brings together biological and chemical information. The software integrates with Oracle®, the industry standard relational database and familiar Microsoft® applications such as Word and Excel.
With all discovery data in one system, the communication of information between scientists is simplified — enabling better, faster decisions — and the need for IT support to integrate disparate systems is eliminated.
IDBS is also pioneering software to predict drug efficacy and safety based on pre-clinical data, complementing the scientific expertise of researchers. By predicting potential problems with compounds earlier in the discovery process, costs are cut and efficiency is boosted.
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In summary, ISG15 expression levels are crucial for trophoblast morphology and function (migration/invasion). By blocking trophoblast invasion, reduced ISG15 levels could contribute to impaired spiral artery transformation that reduces utero-placental blood flow in preeclampsia. Thus, agents inducing ISG15 expression are likely to be therapeutic in preeclampsia.
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Can we use computational methods to identify previously unknown off-targets of PARP inhibitors that can explain their observed differences?READ MORE