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Drug Discovery

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Functional Evaluation of SLC Transporters in BD Gentest™ Cryopreserved Human Hepatocytes Using an Oil-Filtration Suspension Assay

Poster

Published: January 22, 2008

Functional Evaluation of SLC Transporters in BD Gentest™ Cryopreserved Human Hepatocytes Using an Oil-Filtration Suspension Assay content piece image

The purpose of this study was to evaluate the function of Sodium Taurocholate Co-transporting Polypeptide (NTCP), Organic Anion Transporting Polypeptide (OATP), and Organic Cation Transporter (OCT) in cryopreserved human hepatocytes, and to examine the impact of various drugs on hepatic transporter-mediated uptake. Cryopreserved human hepatocytes were prepared using the Percoll™ method.