High Throughput Rheological Characterization of Small Volume Biopharmaceutical Formulations
Poster Jan 18, 2017
Dr. David Nieto Simavilla, Ivan Akhremitchev, & Dr. Seonggi Baek
During the drug discovery process, biopharmaceutical industries produce a large number of formulations with small recipe variations. One important aspect in the development of novel drugs is the characterization of their viscosity fingerprint (i.e. viscosity dependence on shear rate, temperature…). Viscosity is a good indicator of small changes in concentration and molecular structure that play a key role in the efficacy and stability of the final product.
Exploiting Polypharmacology in Precision Oncology: Identification of Differential Kinase Off-targets Among Clinical PARP InhibitorsPoster
Can we use computational methods to identify previously unknown off-targets of PARP inhibitors that can explain their observed differences?READ MORE
Bioluminescent Assay for GTPases Allows Measurement of GTPase, GAP and GEF ActivitiesPoster
We have developed a homogenous bioluminescent assay (GTPase-Glo) system to analyze these proteins in a simple, convenient “add-mix-read” format.READ MORE
NanoBRET™ Assays for Monitoring Protein Interactions in Living CellsPoster
NanoBRET PPI System is composed of two components.
NanoBRET offers improved S:B over other BRET assays.
NanoBRET provides sensitive live-cell method to study protein interactions.