Identification and Quantitation of Mixture Components of Formulated Products by NMR
Poster Dec 17, 2019
Brent G. Pautler, Patrick Wheeler, Sergey Golotvin, Rostislav Pol, Joe DiMartino
It has become increasingly important for chemists and analysts to be able to test and determine the various components that may be present in mixtures, both qualitatively and quantitatively, to solve a wide variety of scientific problems. NMR spectroscopy has emerged as a powerful, non-destructive analytical technique that provides unique information that may not be readily accessible by other means to support the needs of various industries, including polymers, pharmaceuticals, consumer products, and nutrition, to name a few.
The changing landscape for antibody-derived therapeutics, such as bi-specific monoclonal antibodies, Fab fragments and Fc-fusion proteins brings new purification challenges in the downstream processing of these molecules. Standard chromatography resins, such as Protein A, may not result in the most efficient purification process.READ MORE