We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
In silico Screening for Signalosome Inhibitors
Poster

In silico Screening for Signalosome Inhibitors

In silico Screening for Signalosome Inhibitors
Poster

In silico Screening for Signalosome Inhibitors

Abstract
The COP9 signalosome (CSN) is involved in cell cycle regulation, possesses kinase activity (Targets: e.g. p53 and c-Jun) and is therefore an interesting therapeutic target for anti-tumor drugs. Known inhibitors of the kinase activity exhibit low binding constants. Using them a 3D similarity screening for our in-house database is performed. The superposition algorithm enables the explicit consideration of conformers reflecting the structural flexibility. Experimental tests show significant improvement of inhibition.
Advertisement