Interfacing Microwave Synthesis with Enabling Technologies in Drug Discovery
Poster Mar 30, 2006
Doris Dallinger and C. Oliver Kappe
IntroductionModern drug discovery steadily relies on high-speed organic synthesis and combinatorial chemistry techniques for the rapid generation of compound libraries. Microwave-assisted organic synthesis in combination with polymer-assisted solution phase (PASP) methods are powerful techniques that are frequently applied in both academia and industry.
Here we report on the rapid synthesis/decoration of privileged heterocyclic scaffolds, namely the dihydropyrimidine (DHPM) scaffold, by applying microwave heating in conjunction with PASP approaches. The use of resin-bound catalysts, reagents and scavengers as well as fluorous reagents in conjunction with microwave heating will be described for amidations, esterifications via a Mitsunobu protocol and N-acylations.
CiPA Phase 2 Study: validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluationPoster
These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.READ MORE
A luminescent solar concentrator-based photomicroreactor for energy efficient continuous-flow photocatalysisPoster
The Luminescent Solar ConcentratorPhotomicroreactor
(LSC-PM) is an innovative device
for solar-powered continuous-flow photochemistry.