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Isothermal Titration Microcalorimetry: An Essential Tool for Fragment-Based Drug Discovery

Isothermal titration microcalorimetry (ITC) is an essential tool in drug discovery, enabling researchers to study and regulate protein interactions. Recent advancements in ITC instrumentation have led to an increase in the throughput and decrease in the protein consumption of the technique. When combined with the extended affinity range, these factors make the technique ideal for fragment-based drug discovery campaigns.

Download this poster to discover how ITC:

  • Requires minimal assay development and sample preparation
  • Allows early determination and elimination of false positives produced during primary screening
  • Can be used to identify fragments that will form a high resolution co-crystal with the target protein